Assay Detail
Functional
CHEMBL5226008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protection against PFFs induced alpha-synuclein aggregation in human iPSC derived neurons assessed as reduction in phosphorylated S129 alpha-synuclein level pretreated for 1 day followed by PFFs stimulation and measured after 14 days by immunocytochemistry analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275403 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275403 | — | IC50 | = | 17.0 | nM | 7.77 |