Assay Detail
Binding
CHEMBL5226022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Cy5-O-Len from 6His-tagged CRBN/DDB1 (unknown origin) incubated for 1 hr under dark condition by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/DNA damage-binding protein 1 (CHEMBL4630734) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.39 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270900 | — | — | 1 | 8.85 |
| CHEMBL5276245 | — | — | 1 | 8.15 |
| CHEMBL5268757 | — | — | 1 | 7.28 |
| CHEMBL5283559 | — | — | 1 | 6.66 |
| CHEMBL5271340 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270900 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5276245 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5268757 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5283559 | — | IC50 | = | 217.3 | nM | 6.66 |
| CHEMBL5271340 | — | IC50 | = | 1028.7 | nM | 5.99 |