Assay Detail
Functional
CHEMBL5226038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MIA PaCa-2 cells harboring G12C mutant assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Bioevaluation of Pyrido[2,3-<i>d</i>]pyrimidin-7-ones as Potent SOS1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.86 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5274267 | — | — | 1 | 7.56 |
| CHEMBL4519023 | — | — | 1 | 7.52 |
| CHEMBL5280533 | — | — | 1 | 7.13 |
| CHEMBL5290547 | — | — | 1 | 7.04 |
| CHEMBL5275216 | — | — | 1 | 7.04 |
| CHEMBL5286601 | — | — | 1 | 6.81 |
| CHEMBL5280431 | — | — | 1 | 6.80 |
| CHEMBL5266985 | — | — | 1 | 6.72 |
| CHEMBL5269963 | — | — | 1 | 6.50 |
| CHEMBL5267612 | — | — | 1 | 6.47 |
| CHEMBL5284292 | — | — | 1 | 6.37 |
| CHEMBL5275839 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5274267 | — | IC50 | = | 27.7 | nM | 7.56 |
| CHEMBL4519023 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5280533 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL5290547 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5275216 | — | IC50 | = | 90.1 | nM | 7.04 |
| CHEMBL5286601 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5280431 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5266985 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5269963 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL5267612 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5284292 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL5275839 | — | IC50 | = | 459.0 | nM | 6.34 |