Assay Detail
Binding
CHEMBL5226418
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Inhibition of HDAC1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.27 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.52 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.75 |
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 7.46 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 7.24 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.12 |
| CHEMBL5280773 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5280773 | — | IC50 | = | 2820.0 | nM | 5.55 |