Assay Detail
Binding
CHEMBL5226423
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Inhibition of HDAC6 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.73 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 8.59 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.33 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.96 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.82 |
| CHEMBL178456 | — | — | 1 | 7.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.57 |
| CHEMBL5280773 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL178456 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5280773 | — | IC50 | = | 680.0 | nM | 6.17 |