Assay Detail
Binding
CHEMBL5226446
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Inhibition of human HDAC6 using FAM-labeled acetylated peptide as substrate incubated for 17 hrs by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.41 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3938429 | — | — | 1 | 6.68 |
| CHEMBL3966183 | — | — | 1 | 6.41 |
| CHEMBL3947997 | — | — | 1 | 6.35 |
| CHEMBL3919705 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3938429 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3966183 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3947997 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3919705 | — | IC50 | = | 660.0 | nM | 6.18 |