Assay Detail
Binding
CHEMBL5226450
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Inhibition of human full length recombinant HDAC1 expressed in baculovirus infected Sf9 cells using RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 2 hrs by fluorescence based analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.27 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280419 | — | — | 1 | 5.82 |
| CHEMBL5283611 | — | — | 1 | 5.57 |
| CHEMBL5271952 | — | — | 1 | 5.43 |
| CHEMBL2417783 | — | — | 1 | 5.24 |
| CHEMBL5288844 | — | — | 1 | 5.02 |
| CHEMBL5265776 | — | — | 1 | 4.55 |
| CHEMBL5272849 | — | — | 1 | - |
| CHEMBL2417784 | — | — | 1 | - |
| CHEMBL5270751 | — | — | 1 | - |
| CHEMBL5266668 | — | — | 1 | - |
| CHEMBL5289739 | — | — | 1 | - |
| CHEMBL5283275 | — | — | 1 | - |
| CHEMBL5280016 | — | — | 1 | - |
| CHEMBL5279117 | — | — | 1 | - |
| CHEMBL5281887 | — | — | 1 | - |
| CHEMBL5273398 | — | — | 1 | - |
| CHEMBL5290438 | — | — | 1 | - |
| CHEMBL5271068 | — | — | 1 | - |
| CHEMBL5268067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280419 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5283611 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5271952 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2417783 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5288844 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5265776 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL5272849 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2417784 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5270751 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5266668 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5289739 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5283275 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5280016 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5279117 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5281887 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5273398 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5290438 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5271068 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5268067 | — | IC50 | > | 30000.0 | nM | - |