Assay Detail

CHEMBL5226508

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Binding

Agonist activity at TLR2 in HEK-Blue hTLR2 cells

ChEMBL ↗

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Target

Toll-like receptor 2 (CHEMBL4163) ↗

Open DB target context

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Primary target Toll-like receptor 2

CHEMBL4163

Anchored from Assay target.

Protein identity Toll-like receptor 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Cell Type	HEK-Blue hTLR2
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Toll-like receptor 2 (CHEMBL4163) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

TLR2 Agonistic Small Molecules: Detailed Structure-Activity Relationship, Applications, and Future Prospects.

Kaur A, Kaushik D, Piplani S, Mehta SK, Petrovsky N, Salunke DB.
J Med Chem (2021) 64 : 233 -278
PubMed 33346636 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.26	6.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5284224	—	—	1	6.26
CHEMBL4581678	—	—	1	6.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5284224	—	EC50	=	550.0	nM	6.26
CHEMBL4581678	—	EC50	=	550.0	nM	6.26