Assay Detail
Binding
CHEMBL5226587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain aSMase using HMU-PC as substrate incubated for 3 hrs by fluorescence plate reader assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.34 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5288063 | — | — | 1 | 7.70 |
| CHEMBL4553570 | — | — | 1 | 7.40 |
| CHEMBL416301 | — | — | 1 | 7.16 |
| CHEMBL54004 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5288063 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4553570 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL416301 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL54004 | — | IC50 | = | 80.0 | nM | 7.10 |