Assay Detail
Binding
CHEMBL5226627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE9A (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (CHEMBL3535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.67 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5285855 | — | — | 1 | 7.96 |
| CHEMBL4642517 | — | — | 1 | 7.80 |
| CHEMBL4644938 | — | — | 1 | 7.25 |
| CHEMBL4649493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5285855 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4642517 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4644938 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4649493 | — | IC50 | > | 10000.0 | nM | - |