Assay Detail
Binding
CHEMBL5226638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE10A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.73 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276846 | — | — | 1 | 7.28 |
| CHEMBL5269828 | — | — | 1 | 6.17 |
| CHEMBL5267226 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5276846 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5269828 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5267226 | — | IC50 | > | 1000.0 | nM | - |