Assay Detail
Binding
CHEMBL5226653
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5A1 (unknown origin) using FAM-cGMP as substrate incubated for 60 mins by IMAP-fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.59 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275356 | — | — | 1 | 7.82 |
| CHEMBL5271210 | — | — | 1 | 7.50 |
| CHEMBL4435044 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275356 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5271210 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4435044 | — | IC50 | = | 36.0 | nM | 7.44 |