Assay Detail
Binding
CHEMBL5226655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE5A using FL-cGMP as substrate incubated for 1.5 hrs by IMAP-fluorescence polarization assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.76 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288354 | — | — | 1 | 6.80 |
| CHEMBL4288752 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288354 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4288752 | — | IC50 | = | 190.0 | nM | 6.72 |