Assay Detail
Binding
CHEMBL5226662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse PDE9A expressed in baculovirus infected Sf9 insect cells using 3[H]-cGMP as substrate incubated for 60 mins by scintillation proximity assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (CHEMBL5169102) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.66 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636079 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636079 | — | IC50 | = | 22.0 | nM | 7.66 |