Assay Detail
Binding
CHEMBL5226665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length PDE1B in human myocardium using cAMP as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Myocardium |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (CHEMBL4425) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.14 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128481 | — | — | 1 | 8.05 |
| CHEMBL4129844 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128481 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4129844 | — | IC50 | = | 596.0 | nM | 6.22 |