Assay Detail

CHEMBL5226880

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Functional

Antiproliferative activity against human LoVo cells assessed as reduction in cell viability

ChEMBL ↗

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Target

LoVo (CHEMBL614721) ↗

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Primary target LoVo

CHEMBL614721

Anchored from Assay target.

Protein identity LoVo

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	LoVo
Confidence	1 — Organism
Curated By	Autocuration

Target

LoVo (CHEMBL614721) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.

Phull MS, Jadav SS, Gundla R, Mainkar PS.
Eur J Med Chem (2021) 212 : 113149 -113149
PubMed 33445154 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.74	4.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL501756	BRUCINE	-1.0	1	4.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL501756	BRUCINE	IC50	=	18250.0	nM	4.74