Assay Detail
Binding
CHEMBL5226909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wnt/beta-catenin signaling pathway in mouse L Wnt-3A cells harbouring STF-reporter gene assessed as assessed as reduction in luciferase activity incubated for 24 hrs by luciferase reporter assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L Wnt-3A |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.45 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280076 | — | — | 1 | 7.60 |
| CHEMBL5280382 | — | — | 1 | 7.57 |
| CHEMBL5281036 | — | — | 1 | 7.40 |
| CHEMBL1257063 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280076 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5280382 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5281036 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1257063 | — | IC50 | = | 58.0 | nM | 7.24 |