Assay Detail
Functional
CHEMBL5227040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV infected in HEK293T cells expressing human ACE2 assessed as inhibition of viral replication incubated for 2 days by Dual-Glo luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.17 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91704 | K-777 | 2.0 | 1 | 9.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91704 | K-777 | IC50 | = | 0.68 | nM | 9.17 |