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Assay Detail

CHEMBL5227057

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Functional
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type EFM-19
Confidence 1 — Organism
Curated By Autocuration

Target

EFM-19 (CHEMBL1075439)
Type CELL-LINE
Organism Homo sapiens

Publication

Nonpungent N-AVAM Capsaicin Analogues and Cancer Therapy.
Richbart SD, Friedman JR, Brown KC, Gadepalli RS, Miles SL, Rimoldi JM, Rankin GO, Valentovic MA, Tirona MT, Finch PT, Hess JA, Dasgupta P.
J Med Chem (2021) 64 : 1346 -1361
PubMed 33508189 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.14 6.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123254 1 6.26
CHEMBL76903 OLVANIL 2.0 1 6.16
CHEMBL1672669 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123254 IC50 = 550.0 nM 6.26
CHEMBL76903 OLVANIL IC50 = 700.0 nM 6.16
CHEMBL1672669 IC50 = 1000.0 nM 6.00