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Assay Detail

CHEMBL5227119

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PARP1 (unknown origin) using NAD+ as substrate incubated for 60 mins by ELISA
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Poly [ADP-ribose] polymerase 1 (CHEMBL3105)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development.
Tang P, Zhang J, Liu J, Chiang CM, Ouyang L.
J Med Chem (2021) 64 : 2419 -2435
PubMed 33616410 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.34 5.34
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5205994 2 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5205994 IC50 = 4600.0 nM 5.34
CHEMBL5205994 Inhibition < 60.0 % -