Assay Detail

CHEMBL5227224

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Functional

Anticancer activity against human Hs-578T cells assessed as cell growth inhibition by MTS assay

ChEMBL ↗

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Target

Hs-578T (CHEMBL614645) ↗

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Hs-578T (CHEMBL614645) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Hs-578T

CHEMBL614645

Anchored from Assay target.

Protein identity Hs-578T

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Hs-578T
Confidence	1 — Organism
Curated By	Autocuration

Target

Hs-578T (CHEMBL614645) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions.

Liao M, Zhang J, Wang G, Wang L, Liu J, Ouyang L, Liu B.
J Med Chem (2021) 64 : 2382 -2418
PubMed 33650861 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.10	6.90

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1454946	FLUBENDAZOLE	2.0	1	6.90
CHEMBL3986860	—	—	1	5.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1454946	FLUBENDAZOLE	IC50	=	125.0	nM	6.90
CHEMBL3986860	—	IC50	=	5000.0	nM	5.30