Assay Detail
Binding
CHEMBL5227263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human gamma secretase by western blot assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-secretase-activating protein (CHEMBL3638343) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.21 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1770916 | NIROGACESTAT | 4.0 | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1770916 | NIROGACESTAT | IC50 | = | 6.2 | nM | 8.21 |