Assay Detail
Binding
CHEMBL5227316
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Inhibition of Wnt pathway (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.38 | 10.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2139947 | — | — | 1 | 10.13 |
| CHEMBL3623895 | — | — | 1 | 9.96 |
| CHEMBL5269295 | — | — | 1 | 9.30 |
| CHEMBL4546441 | — | — | 1 | 9.10 |
| CHEMBL3188386 | WNT-974 | 2.0 | 1 | 9.00 |
| CHEMBL3759008 | — | — | 1 | 8.64 |
| CHEMBL4540197 | — | — | 1 | 7.92 |
| CHEMBL1257064 | — | — | 1 | 7.57 |
| CHEMBL5274620 | — | — | 1 | 7.24 |
| CHEMBL3814761 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2139947 | — | IC50 | = | 0.074 | nM | 10.13 |
| CHEMBL3623895 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5269295 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4546441 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3188386 | WNT-974 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3759008 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4540197 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1257064 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5274620 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3814761 | — | IC50 | = | 12500.0 | nM | 4.90 |