Assay Detail
Binding
CHEMBL5227380
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Inhibition of Wnt/beta-catenin signaling pathway in human COLO 320DM cells assessed as reduction in AXIN2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COLO 320DM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.73 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5185515 | — | — | 1 | 5.70 |
| CHEMBL3589156 | — | — | 1 | 4.82 |
| CHEMBL3589012 | — | — | 1 | 4.52 |
| CHEMBL3589019 | — | — | 1 | 4.51 |
| CHEMBL3589160 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5185515 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3589156 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3589012 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3589019 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3589160 | — | IC50 | = | 76000.0 | nM | 4.12 |