Assay Detail
Binding
CHEMBL5227423
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Inhibition of Erk2 (unknown origin)
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.11 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | — | 2 | 8.35 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 5.70 |
| CHEMBL296586 | KENPAULLONE | — | 2 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 9.0 | nM | - |