Assay Detail
Binding
CHEMBL5227434
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Inhibition of Chk2 (unknown origin)
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.29 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481333 | — | — | 1 | 8.10 |
| CHEMBL1947252 | — | — | 1 | 7.85 |
| CHEMBL1947250 | — | — | 1 | 7.70 |
| CHEMBL1947253 | — | — | 1 | 7.55 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.38 |
| CHEMBL1944822 | — | — | 1 | 6.81 |
| CHEMBL1944823 | — | — | 1 | 6.77 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 2 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481333 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1947252 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1947250 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1947253 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1944822 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL1944823 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 183.0 | nM | 6.74 |