Assay Detail
Binding
CHEMBL5227478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Plasmodium falciparum GSK3 using GS-1 peptide as substrate in presence of [gamma-32P]ATP measured after 30 mins incubation by scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.43 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.00 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.64 |
| CHEMBL216543 | — | — | 1 | 7.19 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 6.50 |
| CHEMBL5280328 | — | — | 1 | 5.82 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 5.10 |
| CHEMBL430574 | PAULLONE | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL216543 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5280328 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL430574 | PAULLONE | IC50 | = | 18000.0 | nM | 4.75 |