Assay Detail

CHEMBL5227536

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human PDE4D7

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 3',5'-cyclic-AMP phosphodiesterase 4D

CHEMBL288

Anchored from Assay target.

Protein identity 3',5'-cyclic-AMP phosphodiesterase 4D

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery.

Sun J, Xiao Z, Haider A, Gebhard C, Xu H, Luo HB, Zhang HT, Josephson L, Wang L, Liang SH.
J Med Chem (2021) 64 : 7083 -7109
PubMed 34042442 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.11	8.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4541964	ZATOLMILAST	3.0	1	8.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4541964	ZATOLMILAST	IC50	=	7.8	nM	8.11