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Assay Detail

CHEMBL5227545

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PDE7 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Phosphodiesterase 7 (CHEMBL2111411)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery.
Sun J, Xiao Z, Haider A, Gebhard C, Xu H, Luo HB, Zhang HT, Josephson L, Wang L, Liang SH.
J Med Chem (2021) 64 : 7083 -7109
PubMed 34042442 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 8.27 8.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5180503 1 8.77
CHEMBL5196667 1 7.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5180503 IC50 = 1.7 nM 8.77
CHEMBL5196667 IC50 = 17.0 nM 7.77