Assay Detail
Binding
CHEMBL5227876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PP5 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 5 (CHEMBL3425389) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | — | 1 | 9.00 |
| CHEMBL5268133 | — | — | 1 | 8.46 |
| CHEMBL505512 | TAUTOMYCIN | — | 1 | 8.00 |
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5268133 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL505512 | TAUTOMYCIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 600.0 | nM | 6.22 |