Assay Detail
Binding
CHEMBL5227879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PP5 using [3H]-phosphohistone as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 5 (CHEMBL3425389) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430266 | CALYCULIN A | — | 1 | 8.52 |
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430266 | CALYCULIN A | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 400.0 | nM | 6.40 |