Assay Detail

CHEMBL5227934

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Anticancer activity against human HT-29 cells incubated for 48 hrs by MTT assay

ChEMBL ↗

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Target

HT-29 (CHEMBL384) ↗

Open DB target context

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HT-29 (CHEMBL384) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HT-29

CHEMBL384

Anchored from Assay target.

Protein identity HT-29

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HT-29
Confidence	1 — Organism
Curated By	Autocuration

Target

HT-29 (CHEMBL384) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise.

Khaiwa N, Maarouf NR, Darwish MH, Alhamad DWM, Sebastian A, Hamad M, Omar HA, Orive G, Al-Tel TH.
Eur J Med Chem (2021) 223 : 113639 -113639
PubMed 34175539 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.16	7.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5276794	—	—	1	7.16

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5276794	—	IC50	=	70.0	nM	7.16