Assay Detail
Binding
CHEMBL5228260
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flunitrazepam from CBR receptor in rat brain cortex membrane incubated for 20 mins by liquid scintillation spectrometer method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 9.00 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.25 |
| CHEMBL338738 | — | — | 1 | 6.07 |
| CHEMBL134590 | — | — | 1 | - |
| CHEMBL334887 | — | — | 1 | - |
| CHEMBL5283306 | — | — | 1 | - |
| CHEMBL335049 | — | — | 1 | - |
| CHEMBL136030 | — | — | 1 | - |
| CHEMBL137730 | — | — | 1 | - |
| CHEMBL135408 | — | — | 1 | - |
| CHEMBL335923 | — | — | 1 | - |
| CHEMBL97269 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54349 | ALPIDEM | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL12 | DIAZEPAM | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL338738 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL134590 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL334887 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5283306 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL335049 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL136030 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL137730 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL135408 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL335923 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL97269 | — | IC50 | > | 1000.0 | nM | - |