Assay Detail

CHEMBL5228427

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Binding

Inhibition of Severe acute respiratory syndrome coronavirus proteinase 3C using Dabcy-KTSAVLQSGFRKME-Edans peptide as a substrate

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Severe acute respiratory syndrome-related coronavirus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthetic and computational efforts towards the development of peptidomimetics and small-molecule SARS-CoV 3CLpro inhibitors.

Paul A, Sarkar A, Saha S, Maji A, Janah P, Kumar Maity T.
Bioorg Med Chem (2021) 46 : 116301 -116301
PubMed 34332853 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.70	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL477164	—	—	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL477164	—	IC50	=	200.0	nM	6.70