Assay Detail
Binding
CHEMBL5228434
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Inhibition of PRC2 (unknown origin) using H3K27me0 as peptide substrate by LC-MS based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Polycomb Repressive Complex 2 Modulation through the Development of EZH2-EED Interaction Inhibitors and EED Binders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.40 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097892 | — | — | 1 | 5.60 |
| CHEMBL5283723 | — | — | 1 | 5.39 |
| CHEMBL310238 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097892 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5283723 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL310238 | — | IC50 | = | 6040.0 | nM | 5.22 |