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Assay Detail

CHEMBL5228447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against mouse J774A.1 cells measured after 1 hr in dark by SYBR Green I assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Mus musculus
Cell Type J774.A1
Confidence 1 — Organism
Curated By Autocuration

Target

J774.A1 (CHEMBL614040)
Type CELL-LINE
Organism Mus musculus

Publication

Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.
Hammill JT, Sviripa VM, Kril LM, Ortiz D, Fargo CM, Kim HS, Chen Y, Rector J, Rice AL, Domagalska MA, Begley KL, Liu C, Rangnekar VM, Dujardin JC, Watt DS, Landfear SM, Guy RK.
J Med Chem (2021) 64 : 12152 -12162
PubMed 34355566 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 34 5.43 6.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5282456 1 6.36
CHEMBL5277642 1 6.25
CHEMBL5289115 1 6.05
CHEMBL5290790 1 6.00
CHEMBL5271856 1 5.85
CHEMBL5267219 1 5.85
CHEMBL5267300 1 5.80
CHEMBL5269837 1 5.66
CHEMBL5283798 1 5.62
CHEMBL5276610 1 5.54
CHEMBL5286937 1 5.50
CHEMBL5266492 1 5.43
CHEMBL5277993 1 5.43
CHEMBL5270715 1 5.43
CHEMBL5270130 1 5.39
CHEMBL5290663 1 5.36
CHEMBL5284173 1 5.32
CHEMBL5272183 1 5.31
CHEMBL5266105 1 5.31
CHEMBL5271609 1 5.31
CHEMBL5289451 1 5.29
CHEMBL5279286 1 5.17
CHEMBL5285840 1 5.17
CHEMBL5270247 1 5.06
CHEMBL5273799 1 5.01
CHEMBL5278212 1 5.00
CHEMBL5266087 1 4.92
CHEMBL5288777 1 4.89
CHEMBL5286763 1 4.85
CHEMBL5285534 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5282456 EC50 = 440.0 nM 6.36
CHEMBL5277642 EC50 = 560.0 nM 6.25
CHEMBL5289115 EC50 = 890.0 nM 6.05
CHEMBL5290790 EC50 = 1000.0 nM 6.00
CHEMBL5271856 EC50 = 1400.0 nM 5.85
CHEMBL5267219 EC50 = 1400.0 nM 5.85
CHEMBL5267300 EC50 = 1600.0 nM 5.80
CHEMBL5269837 EC50 = 2200.0 nM 5.66
CHEMBL5283798 EC50 = 2400.0 nM 5.62
CHEMBL5276610 EC50 = 2900.0 nM 5.54
CHEMBL5286937 EC50 = 3200.0 nM 5.50
CHEMBL5266492 EC50 = 3700.0 nM 5.43
CHEMBL5277993 EC50 = 3700.0 nM 5.43
CHEMBL5270715 EC50 = 3700.0 nM 5.43
CHEMBL5270130 EC50 = 4100.0 nM 5.39
CHEMBL5290663 EC50 = 4400.0 nM 5.36
CHEMBL5284173 EC50 = 4800.0 nM 5.32
CHEMBL5272183 EC50 = 4900.0 nM 5.31
CHEMBL5271609 EC50 = 4900.0 nM 5.31
CHEMBL5266105 EC50 = 4900.0 nM 5.31
CHEMBL5289451 EC50 = 5100.0 nM 5.29
CHEMBL5279286 EC50 = 6800.0 nM 5.17
CHEMBL5285840 EC50 = 6800.0 nM 5.17
CHEMBL5270247 EC50 = 8700.0 nM 5.06
CHEMBL5273799 EC50 = 9800.0 nM 5.01
CHEMBL5278212 EC50 = 10000.0 nM 5.00
CHEMBL5266087 EC50 = 12000.0 nM 4.92
CHEMBL5288777 EC50 = 13000.0 nM 4.89
CHEMBL5286763 EC50 = 14000.0 nM 4.85
CHEMBL5285534 EC50 = 16000.0 nM 4.80
CHEMBL5270105 EC50 - -
CHEMBL5279169 EC50 - -
CHEMBL5281166 EC50 - -
CHEMBL5274264 EC50 - -