Assay Detail
Functional
CHEMBL5228450
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Antileishmanial activity against antimony-resistant Leishmania donovani BPK275 promastigote infected in mouse J774A.1 cells assessed as inhibition of intracellular amastigotes growth measured after 72 hrs by Renilla luciferase assay system
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | J774.A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.85 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.57 |
| CHEMBL5270715 | — | — | 1 | 6.15 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.92 |
| CHEMBL2219662 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5270715 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2219662 | — | EC50 | = | 18000.0 | nM | 4.75 |