Assay Detail
Binding
CHEMBL5228992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(R)-(+)7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D<sub>2</sub> or D<sub>3</sub> Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.82 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5273118 | — | — | 1 | 8.69 |
| CHEMBL5273776 | — | — | 1 | 8.34 |
| CHEMBL5287555 | — | — | 1 | 8.02 |
| CHEMBL5286161 | — | — | 1 | 7.31 |
| CHEMBL5288831 | — | — | 1 | 7.25 |
| CHEMBL419792 | SUMANIROLE | 3.0 | 1 | 7.09 |
| CHEMBL5267958 | — | — | 1 | 7.09 |
| CHEMBL4744811 | — | — | 1 | 7.06 |
| CHEMBL5291065 | — | — | 1 | 7.06 |
| CHEMBL4551160 | — | — | 1 | 7.06 |
| CHEMBL5274609 | — | — | 1 | 6.96 |
| CHEMBL5280481 | — | — | 1 | 6.94 |
| CHEMBL5286603 | — | — | 1 | 6.43 |
| CHEMBL4437740 | — | — | 1 | 6.08 |
| CHEMBL4764883 | — | — | 1 | 6.00 |
| CHEMBL5277640 | — | — | 1 | 5.88 |
| CHEMBL4464060 | — | — | 1 | 5.76 |
| CHEMBL5280797 | — | — | 1 | 5.73 |
| CHEMBL5266180 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5273118 | — | Ki | = | 2.03 | nM | 8.69 |
| CHEMBL5273776 | — | Ki | = | 4.58 | nM | 8.34 |
| CHEMBL5287555 | — | Ki | = | 9.56 | nM | 8.02 |
| CHEMBL5286161 | — | Ki | = | 49.1 | nM | 7.31 |
| CHEMBL5288831 | — | Ki | = | 55.9 | nM | 7.25 |
| CHEMBL419792 | SUMANIROLE | Ki | = | 80.6 | nM | 7.09 |
| CHEMBL5267958 | — | Ki | = | 80.8 | nM | 7.09 |
| CHEMBL4744811 | — | Ki | = | 86.2 | nM | 7.06 |
| CHEMBL5291065 | — | Ki | = | 86.7 | nM | 7.06 |
| CHEMBL4551160 | — | Ki | = | 87.8 | nM | 7.06 |
| CHEMBL5274609 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL5280481 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL5286603 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL4437740 | — | Ki | = | 831.0 | nM | 6.08 |
| CHEMBL4764883 | — | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL5277640 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL4464060 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL5280797 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL5266180 | — | Ki | = | 13500.0 | nM | 4.87 |