Assay Detail
Binding
CHEMBL5228993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(R)-(+)7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D<sub>2</sub> or D<sub>3</sub> Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.12 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4551160 | — | — | 1 | 8.73 |
| CHEMBL5267958 | — | — | 1 | 8.24 |
| CHEMBL5288831 | — | — | 1 | 8.13 |
| CHEMBL5291065 | — | — | 1 | 8.09 |
| CHEMBL5273118 | — | — | 1 | 7.71 |
| CHEMBL4744811 | — | — | 1 | 7.68 |
| CHEMBL5286161 | — | — | 1 | 7.66 |
| CHEMBL5280481 | — | — | 1 | 7.65 |
| CHEMBL5274609 | — | — | 1 | 7.51 |
| CHEMBL5273776 | — | — | 1 | 7.11 |
| CHEMBL5287555 | — | — | 1 | 6.97 |
| CHEMBL5286603 | — | — | 1 | 6.81 |
| CHEMBL4464060 | — | — | 1 | 6.73 |
| CHEMBL4437740 | — | — | 1 | 6.55 |
| CHEMBL4764883 | — | — | 1 | 6.37 |
| CHEMBL5277640 | — | — | 1 | 6.20 |
| CHEMBL419792 | SUMANIROLE | 3.0 | 1 | 6.11 |
| CHEMBL5280797 | — | — | 1 | 5.86 |
| CHEMBL5266180 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4551160 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL5267958 | — | Ki | = | 5.72 | nM | 8.24 |
| CHEMBL5288831 | — | Ki | = | 7.41 | nM | 8.13 |
| CHEMBL5291065 | — | Ki | = | 8.13 | nM | 8.09 |
| CHEMBL5273118 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL4744811 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5286161 | — | Ki | = | 22.1 | nM | 7.66 |
| CHEMBL5280481 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL5274609 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL5273776 | — | Ki | = | 77.1 | nM | 7.11 |
| CHEMBL5287555 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL5286603 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL4464060 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL4437740 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL4764883 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL5277640 | — | Ki | = | 625.0 | nM | 6.20 |
| CHEMBL419792 | SUMANIROLE | Ki | = | 784.0 | nM | 6.11 |
| CHEMBL5280797 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL5266180 | — | Ki | = | 6860.0 | nM | 5.16 |