Assay Detail
Binding
CHEMBL5229034
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Inhibition of Menin to MLL (unknown origin) protein-protein interaction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Menin/Histone-lysine N-methyltransferase MLL (CHEMBL2093861) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Recent Progress of Small Molecule Menin-MLL Interaction Inhibitors as Therapeutic Agents for Acute Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.93 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282452 | — | — | 1 | 9.00 |
| CHEMBL5273787 | — | — | 1 | 7.40 |
| CHEMBL5267644 | — | — | 1 | 4.40 |
| CHEMBL3586089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282452 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5273787 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5267644 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3586089 | — | IC50 | = | 446000.0 | nM | - |