Assay Detail
Binding
CHEMBL5229036
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Inhibition of human Menin to MLL protein-protein interaction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Menin/Histone-lysine N-methyltransferase MLL (CHEMBL2093861) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Recent Progress of Small Molecule Menin-MLL Interaction Inhibitors as Therapeutic Agents for Acute Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.70 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5272148 | — | — | 1 | 9.30 |
| CHEMBL4216333 | — | — | 1 | 9.08 |
| CHEMBL5277316 | — | — | 1 | 8.33 |
| CHEMBL5272633 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5272148 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4216333 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL5277316 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5272633 | — | IC50 | = | 8.0 | nM | 8.10 |