Assay Detail
Toxicity
CHEMBL5229245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by KdELECT kinase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.25 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468963 | GW779439X | — | 1 | 7.36 |
| CHEMBL5283441 | — | — | 1 | 6.16 |
| CHEMBL5282194 | — | — | 1 | 5.24 |
| CHEMBL5283475 | — | — | 1 | - |
| CHEMBL5283041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468963 | GW779439X | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL5283441 | — | Kd | = | 690.0 | nM | 6.16 |
| CHEMBL5282194 | — | Kd | = | 5800.0 | nM | 5.24 |
| CHEMBL5283475 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5283041 | — | Kd | > | 10000.0 | nM | - |