Assay Detail
Toxicity
CHEMBL5229246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human partial length Pim1 (A15 to K313 residues ) expressed in bacterial expression system by KdELECT kinase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.95 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468963 | GW779439X | — | 1 | 7.20 |
| CHEMBL5283441 | — | — | 1 | 5.66 |
| CHEMBL5282194 | — | — | 1 | 5.66 |
| CHEMBL5283475 | — | — | 1 | 5.28 |
| CHEMBL5283041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468963 | GW779439X | Kd | = | 63.0 | nM | 7.20 |
| CHEMBL5283441 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL5282194 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL5283475 | — | Kd | = | 5200.0 | nM | 5.28 |
| CHEMBL5283041 | — | Kd | > | 10000.0 | nM | - |