Assay Detail
Binding
CHEMBL5229258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant ADAM17 (unknown origin) using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and measured for 6 hrs by fluorometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.72 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431028 | — | — | 1 | 8.72 |
| CHEMBL5283335 | — | — | 1 | 7.62 |
| CHEMBL5267938 | — | — | 1 | 7.28 |
| CHEMBL5276957 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431028 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5283335 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5267938 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5276957 | — | IC50 | = | 55.0 | nM | 7.26 |