Assay Detail
Binding
CHEMBL5229262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins by fluorescence based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.35 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431028 | — | — | 1 | 8.03 |
| CHEMBL5283335 | — | — | 1 | 7.39 |
| CHEMBL5267938 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431028 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5283335 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5267938 | — | IC50 | = | 242.0 | nM | 6.62 |