Assay Detail
Binding
CHEMBL5229266
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of CD23 shedding by measuring reduction of soluble CD23 release in cell supernatants incubated for 24 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 8 (CHEMBL5665) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.49 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431028 | — | — | 1 | 6.92 |
| CHEMBL5283335 | — | — | 1 | 6.46 |
| CHEMBL5276957 | — | — | 1 | 6.10 |
| CHEMBL5267938 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431028 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5283335 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5276957 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5267938 | — | IC50 | > | 1500.0 | nM | - |