Assay Detail
Binding
CHEMBL5229274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant His6 tagged SENP1 catalytic domain expressed in Escherichia coli BL21 (DE3) using SUMO3-AMC as substrate incubated for 15 mins followed by substrate addition by fluorescence based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.95 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5289965 | — | — | 1 | 5.92 |
| CHEMBL5287448 | — | — | 1 | 4.57 |
| CHEMBL5289490 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5289965 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5287448 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5289490 | — | IC50 | = | 44000.0 | nM | 4.36 |