Assay Detail
Binding
CHEMBL5229290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 protease
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Pseudoprolines as stereoelectronically tunable proline isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.87 | 8.55 |
| Ki | 2 | 9.31 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300891 | — | — | 1 | 9.48 |
| CHEMBL414640 | — | — | 2 | 9.13 |
| CHEMBL5280289 | — | — | 1 | 8.55 |
| CHEMBL5271231 | — | — | 1 | 8.06 |
| CHEMBL5270344 | — | — | 1 | 7.51 |
| CHEMBL3349847 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300891 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL414640 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL5280289 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL414640 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5271231 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5270344 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3349847 | — | IC50 | = | 89.0 | nM | 7.05 |