Assay Detail
Functional
CHEMBL5229420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by FMCA assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from <i>Geophila repens</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.75 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285275 | — | — | 1 | 6.58 |
| CHEMBL5271959 | — | — | 1 | 5.70 |
| CHEMBL5291484 | — | — | 1 | 5.66 |
| CHEMBL5283188 | — | — | 1 | 5.58 |
| CHEMBL5290770 | — | — | 1 | 5.21 |
| CHEMBL4211294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285275 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5271959 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5291484 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5283188 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5290770 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4211294 | — | IC50 | > | 10000.0 | nM | - |