Assay Detail
Binding
CHEMBL5229424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of bacterial inner membrane permeabilization in Escherichia coli assessed as carboxyfluorescein leakage measured for 45 mins by fluorescence based microplate reader assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 2 — Organism |
| Curated By | Autocuration |
Publication
Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from <i>Geophila repens</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.93 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5271959 | — | — | 1 | 7.16 |
| CHEMBL4211294 | — | — | 1 | 7.03 |
| CHEMBL5290770 | — | — | 1 | 6.85 |
| CHEMBL5283188 | — | — | 1 | 6.80 |
| CHEMBL5291484 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5271959 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4211294 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5290770 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5283188 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5291484 | — | EC50 | = | 160.0 | nM | 6.80 |